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Updated: Apr 26, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Primary rectal malignant melanoma-case report
P Gavriilidis1, E Moula2, A Nikolaidou2
1Department of Surgical Oncology, Theageneio Anticancer Hospital, Thessaloniki, Greece.
Primary rectal melanoma is exceptionally rare. This case report details a 79-year-old woman diagnosed with rectal melanoma, successfully treated with surgery and showing good recovery.
Area of Science:
- Gastroenterology
- Oncology
- Surgical Pathology
Background:
- Primary malignant melanoma originating in the rectal mucosa is an exceedingly rare clinical entity.
- Rectal bleeding and tenesmus are common symptoms that can mask rare conditions.
Purpose of the Study:
- To report a rare case of primary rectal melanoma.
- To highlight diagnostic challenges associated with rectal melanoma.
Main Methods:
- Endoscopic examination of the rectum.
- Biopsy and histological analysis of the rectal mass.
- Surgical resection (abdominoperineal resection).
Main Results:
- A posterior fleshy mass was identified 4.5 cm from the anal verge.
- Biopsies confirmed malignant melanoma.
- The patient recovered well one year post-surgery.
Conclusions:
- Primary rectal melanoma is rare and can be misdiagnosed.
- Histologic variability contributes to diagnostic challenges, often leading to misdiagnosis as lymphoma, carcinoma, or sarcoma.
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