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Updated: Apr 26, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Primary rectal malignant melanoma-case report.

P Gavriilidis¹, E Moula², A Nikolaidou²

¹Department of Surgical Oncology, Theageneio Anticancer Hospital, Thessaloniki, Greece.

|July 18, 2014

Summary

This summary is machine-generated.

Primary rectal melanoma is exceptionally rare. This case report details a 79-year-old woman diagnosed with rectal melanoma, successfully treated with surgery and showing good recovery.

Keywords:

Rectal melanoma anorectal malignancies malignant melanoma

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Area of Science:

Gastroenterology
Oncology
Surgical Pathology

Background:

Primary malignant melanoma originating in the rectal mucosa is an exceedingly rare clinical entity.
Rectal bleeding and tenesmus are common symptoms that can mask rare conditions.

Purpose of the Study:

To report a rare case of primary rectal melanoma.
To highlight diagnostic challenges associated with rectal melanoma.

Main Methods:

Endoscopic examination of the rectum.
Biopsy and histological analysis of the rectal mass.
Surgical resection (abdominoperineal resection).

Main Results:

A posterior fleshy mass was identified 4.5 cm from the anal verge.
Biopsies confirmed malignant melanoma.
The patient recovered well one year post-surgery.

Conclusions:

Primary rectal melanoma is rare and can be misdiagnosed.
Histologic variability contributes to diagnostic challenges, often leading to misdiagnosis as lymphoma, carcinoma, or sarcoma.