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Successful management of an extremely premature infant with congenital candidiasis

Sota Iwatani1, Yuko Murakami2, Masami Mizobuchi3

  • 1Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Suma-Ku, Kobe-Shi, Hyogo, Japan ; These authors contributed equally to this work.

AJP Reports
|July 18, 2014
PubMed

Insights

This case study reports a rare instance of congenital candidiasis in an extremely premature infant. Early diagnosis via skin lesions and prompt antifungal treatment led to a successful outcome without significant complications.

Area of Science:

  • Neonatology
  • Infectious Diseases
  • Dermatology

Background:

  • Congenital candidiasis is an extremely rare neonatal infection.
  • Reported cases in term and preterm infants are fewer than 100.
  • This condition can manifest with diverse clinical symptoms.

Observation:

  • A male infant born at 25 weeks' gestation presented with diffuse erythematous papules.
  • Candida albicans was detected in skin, pharyngeal mucus, gastric fluid, and tracheal aspirate.
  • Histopathology confirmed Candida albicans mycelial invasion of the umbilical cord.

Findings:

  • Blood cultures were negative, indicating a localized infection.
  • The infant received prompt antifungal therapy.
  • Skin lesions showed marked improvement following treatment.

Implications:

  • Characteristic skin lesions are crucial for early diagnosis of Candida infections in neonates.
  • Early and effective antifungal treatment can lead to favorable outcomes in extremely premature infants.
  • This case highlights successful management of a rare neonatal fungal infection.

Keywords:
candida albicanschorioamnionitiscongenital candidiasiserythematous papuleextremely premature infant

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