Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Pathophysiology

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hyperglycemia During Acute Pancreatitis and Progression to Early-Onset Diabetes After Recovery: Preliminary Findings From the Diabetes Related to Acute Pancreatitis and Its Mechanisms (DREAM) Study.

Diabetes care·2026

Same author

Associations between dietary patterns and diabetes in patients with acute pancreatitis: a cross-sectional analysis from the DREAM study.

Nutrition journal·2026

Same author

The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC): 10 Years of Past Accomplishments and Looking Forward to the Next 5 Years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC).

Pancreas·2026

Same author

The Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) 10 years of past accomplishments and looking forward to the next 5 years of the Chronic Pancreatitis Clinical Research Consortium (CPCRC).

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2026

Same author

Dana K. Andersen, MD: Leader, Visionary, Colleague, and Friend for the Pancreas Community.

Pancreas·2025

Same author

Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis.

Diabetes·2025

Search research articles

Related Experiment Video

Updated: Apr 26, 2026

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Chronic pancreatitis.

Anand R Gupte¹, Chris E Forsmark

¹aDivision of Gastroenterology, Hepatology and Nutrition, University of Florida bDivision of Gastroenterology, Malcolm Randall VA Medical Center, Gainesville, Florida, USA.

Current Opinion in Gastroenterology

|July 18, 2014

Summary

Diagnosing chronic pancreatitis early is challenging, but new endoscopic and MRI techniques show promise. Effective management includes addressing nutritional deficiencies, type 3c diabetes, and pain with non-narcotic options before considering surgery.

More Related Videos

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: December 14, 2019

Related Experiment Videos

Last Updated: Apr 26, 2026

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: December 14, 2019

Area of Science:

Gastroenterology
Hepatology
Endocrinology

Background:

Chronic pancreatitis diagnosis remains challenging.
Patients face risks of nutritional deficiencies, osteoporosis, and type 3c diabetes.
Pain management is a significant clinical issue.

Purpose of the Study:

To review key clinical observations in chronic pancreatitis from 2013.
To highlight advancements in diagnosis and treatment strategies.
To emphasize the importance of comprehensive patient management.

Main Methods:

Review of clinical observations and recent literature on chronic pancreatitis.
Evaluation of diagnostic techniques including endoscopic ultrasonography-elastography and MRI.
Assessment of treatment modalities such as nutritional support, diabetes management, pain control, endoscopic therapy, and surgery.

Main Results:

Early diagnosis is difficult; newer imaging techniques show potential.
Nutritional deficiencies, osteoporosis, and type 3c diabetes are common and require intervention.
Antioxidants, neuromodulators, endoscopic therapy, and surgery are treatment options for pain and complications, with surgery offering more durable results.

Conclusions:

Advanced imaging may improve early chronic pancreatitis diagnosis.
Addressing nutritional issues and type 3c diabetes is crucial.
Pain management should prioritize non-narcotic and adjunct therapies, with endoscopic and early surgical interventions being viable options for select patients.