[Experimental study on the application of calcium phosphate bioceramics in repairing periodontal osseous defects]

Two kinds of Tricalcium phosphate Ceramic (TPC) powder and one kind of Calcium pyrophosphate Ceramic (CPC) powder, all prepared by the research group, were used in the animal study. The tissue response to these ceramic and biocompatibility of the ceramic were evaluated histopathologically. First, eighteen male mongrel dogs were divided randomly into six groups, and then, both in mandible and maxilla eight 2-wall osseous defects were created bilaterally in each dog. At each side of jaw, one defect remained empty while the other three defects were implanted with TPC and CPC. The dogs were sacrificed at 2, 4, 8, 16, 24 and 32 weeks after implantation for histologic observation.