Enantiospecific total synthesis of macrolactone Sch 725674
Amit K Bali1, Sunil K Sunnam, Kavirayani R Prasad
1Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, India.
Organic Letters
|July 18, 2014
Abstract:
The enantiospecific total synthesis of 14-membered macrolactone Sch 725674 was accomplished from tartaric acid. Key reactions in the synthesis include the Ley's dithiaketalization of an alkynone derived from the bis-Weinreb amide of tartaric acid, Boord olefination, and ring-closing metathesis of an acrylate ester.
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