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Altered brain network modules induce helplessness in major depressive disorder.

Daihui Peng1, Feng Shi2, Ting Shen3

  • 1Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping South Road, Shanghai 200030, PR China; Department of Radiology and BRIC, University of North Carolina, 130 Mason Farm Road, Chapel Hill, NC 27599-7513, USA.

Journal of Affective Disorders
|July 18, 2014
PubMed
Summary

Major depressive disorder (MDD) shows altered brain functional connectivity (FC) network modules, potentially linked to helplessness. These findings highlight global network reorganization in MDD patients.

Keywords:
Functional connectivityHelplessnessMajor depressive disorderModularitySmall-worldness

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Imaging

Background:

  • Abnormal brain functional connectivity (FC) is implicated in major depressive disorder (MDD).
  • Understanding global FC network patterns and their clinical correlations in MDD remains limited.

Purpose of the Study:

  • To investigate global functional connectivity network patterns in first-episode, medication-naïve major depressive disorder (MDD) patients.
  • To explore the relationship between network topology and clinical characteristics of MDD.

Main Methods:

  • Resting-state functional MRI data from 16 MDD patients and 16 controls.
  • Global FC network analysis using 90 brain regions, assessing small-worldness and modularity.
  • Network-based statistic and regional role analysis (participant coefficient, module degree).

Main Results:

  • No significant alteration in small-world properties in MDD patients.
  • MDD patients displayed 5 atypically reorganized brain modules compared to controls.
  • Positive correlation found between intra-module connectivity and helplessness; decreased FC identified in specific brain regions and subnetworks.

Conclusions:

  • Altered brain module network patterns at the global level are evident in MDD patients.
  • These network alterations may contribute to feelings of helplessness in MDD.
  • Limited sample size restricts detailed clinical characteristic analysis.