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Related Concept Videos

Ventilatory Modes01:14

Ventilatory Modes

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Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
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Full support modes include controlled mechanical ventilation, continuous mandatory...
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Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

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Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
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Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

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Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
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Mechanical Ventilation II: Invasive Ventilation01:23

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Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
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Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

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Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
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Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

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Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
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Related Experiment Video

Updated: Apr 26, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
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"Open lung ventilation optimizes pulmonary function during lung surgery".

John B Downs1, Lary A Robinson2, Michael L Steighner1

  • 1Department of Anesthesiology, Moffitt Cancer Center, Tampa, Florida.

The Journal of Surgical Research
|July 19, 2014
PubMed
Summary
This summary is machine-generated.

The open lung (OV) ventilation strategy improved lung mechanics and oxygenation during major lung resections. This safe and effective approach may reduce postoperative complications in patients undergoing surgery.

Keywords:
Airway pressure release ventilationAnesthesia ventilationLung resectionLung surgeryPostoperative pulmonary complicationsProtective ventilationPulmonary atelectasisThoracic surgery

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Area of Science:

  • Anesthesiology
  • Thoracic Surgery
  • Critical Care Medicine

Background:

  • Evaluating the "open lung" (OV) ventilation strategy in patients undergoing major lung resections.
  • OV involves low tidal volumes, low respiratory rate, low FiO2, and high continuous positive airway pressure.

Purpose of the Study:

  • To assess the safety and efficacy of the OV strategy during major lung resections.
  • To compare OV with conventional ventilator settings (CV) in terms of oxygenation and lung compliance.

Main Methods:

  • Phase I pilot study with twelve consecutive patients undergoing lung resection.
  • Patients received both conventional ventilator settings (CV) and OV strategy, serving as their own controls.
  • Oxygenation, lung compliance, and postoperative outcomes were monitored.

Main Results:

  • OV strategy provided consistent one-lung anesthesia and improved static lung compliance (40 ± 7 vs. 25 ± 4 mL/cm H2O).
  • Postresection oxygenation (SpO2/FiO2) was significantly better with OV (433 ± 11 vs. 386 ± 15).
  • No postoperative atelectasis, infiltrates, supplemental oxygen use, complications, or mortality were observed; mean hospital stay was 4 days.

Conclusions:

  • The OV strategy is safe and effective for lung resection patients, optimizing lung mechanics and gas exchange.
  • This approach may reduce postoperative pulmonary complications and improve surgical outcomes.
  • A randomized trial is planned to confirm the reduction of postoperative pulmonary complications.