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The MOGE(S) classification of cardiomyopathy for clinicians

Eloisa Arbustini1, Navneet Narula2, Luigi Tavazzi3

  • 1Center for Inherited Cardiovascular Diseases, IRCCS Foundation Policlinico San Matteo, Pavia, Italy.

Journal of the American College of Cardiology
|July 19, 2014
PubMed

Insights

Most cardiomyopathies are genetic, often inherited in families. A new MOGE(S) system classifies these heart muscle diseases by morphology, organ involvement, genetics, etiology, and function, aiding diagnosis and research.

Area of Science:

  • Cardiology
  • Genetics
  • Medical Diagnostics

Background:

  • Cardiomyopathies are frequently familial, with autosomal dominant inheritance being most common.
  • Current classifications based on morphofunctional phenotypes have limitations in genetic correlation, risk stratification, and pre-clinical diagnosis.
  • Increasing genetic testing necessitates a comprehensive nosology for accurate cardiomyopathy description.

Purpose of the Study:

  • To introduce and describe the MOGE(S) nosology system for classifying cardiomyopathies.
  • To provide a standardized framework that integrates morphofunctional, organ involvement, genetic, etiological, and functional aspects of cardiomyopathies.
  • To facilitate accurate description and diagnosis of cardiomyopathies in patients and families undergoing genetic testing.

Main Methods:

  • The MOGE(S) system categorizes cardiomyopathies based on Morphology (M), Organ(s) involvement (O), Genetic inheritance pattern (G), Etiology (E), and functional Status (S).
  • Functional status (S) incorporates American College of Cardiology/American Heart Association staging and New York Heart Association functional classification.
  • A web-assisted application supports the MOGE(S) nomenclature for clinical and research use.

Main Results:

  • The MOGE(S) system offers a comprehensive approach to cardiomyopathy classification, encompassing genetic and phenotypic data.
  • It allows for detailed description of cardiomyopathy in both symptomatic and asymptomatic individuals, including family members.
  • The system facilitates grouping cardiomyopathies by etiology, describing complex genetics, and building collaborative registries.

Conclusions:

  • The MOGE(S) nosology provides a unified system for describing cardiomyopathies, integrating diverse clinical and genetic information.
  • This comprehensive classification aids in understanding disease heterogeneity, improving risk assessment, and enabling precise diagnoses.
  • The MOGE(S) system is expected to advance research and clinical management of cardiomyopathies through standardized data collection and collaborative efforts.

Keywords:
cardiomyopathyclassificationgenetics

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