Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.4K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.4K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

7.8K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
7.8K
Mitochondria01:37

Mitochondria

13.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.4K
Mitochondrial Membranes01:45

Mitochondrial Membranes

11.7K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.7K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilizing fibrous cap.

Cardiovascular research·2025
Same author

Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease.

Nature cardiovascular research·2024
Same author

Coronavirus disease 2019-related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities.

Cardiovascular research·2024
Same author

Evaluation of microcirculatory protection in percutaneous revascularisation: A stent implantation technique and device comparison.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2024
Same author

Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease.

Nature cardiovascular research·2024
Same author

Effect of variability of mechanical properties on the predictive capabilities of vulnerable coronary plaques.

Computer methods and programs in biomedicine·2024

Related Experiment Video

Updated: Apr 26, 2026

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

36.5K

Mitochondrial DNA damage and atherosclerosis.

Emma P K Yu1, Martin R Bennett1

  • 1Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.

Trends in Endocrinology and Metabolism: TEM
|July 19, 2014
PubMed
Summary

Mitochondrial DNA damage contributes to cellular dysfunction, promoting inflammation and oxidative stress. This review explores the link between mitochondrial defects and atherosclerosis, highlighting potential therapeutic targets.

Keywords:
atherosclerosisinflammationmitochondria

More Related Videos

Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

6.3K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

10.8K

Related Experiment Videos

Last Updated: Apr 26, 2026

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

36.5K
Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

6.3K
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

10.8K

Area of Science:

  • Cellular Biology
  • Cardiovascular Research
  • Mitochondrial Medicine

Background:

  • Mitochondria generate ATP but also regulate cell death, inflammation, and reactive oxygen species (ROS).
  • Mitochondrial dysfunction is implicated in cell death, inflammation, oxidative stress, and altered metabolism.
  • Atherosclerosis involves these key cellular processes.

Purpose of the Study:

  • To review evidence linking mitochondrial DNA (mtDNA) defects to atherosclerosis.
  • To elucidate the mechanisms connecting mtDNA damage and atherosclerosis.
  • To identify potential therapeutic targets in mitochondrial biology for atherosclerosis.

Main Methods:

  • Literature review of recent evidence.
  • Analysis of mechanisms linking mtDNA defects and atherosclerosis.
  • Identification of therapeutic targets.

Main Results:

  • Mitochondrial dysfunction, driven by mtDNA damage, promotes atherosclerosis.
  • Specific mechanisms linking mtDNA defects to atherosclerotic processes are discussed.
  • Several areas of mitochondrial biology emerge as potential therapeutic targets.

Conclusions:

  • Mitochondrial dysfunction and mtDNA defects play a direct role in promoting atherosclerosis.
  • Targeting mitochondrial pathways offers a promising therapeutic strategy for atherosclerosis.
  • Further research into mitochondrial biology is crucial for developing novel treatments.