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Updated: Jun 6, 2026

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Is duodenal diverticulum a risk factor for sphincterotomy?

D Vaira1, J F Dowsett, A R Hatfield

  • 1Department of Gastroenterology, Middlesex Hospital, London.

Gut
|July 1, 1989
PubMed
Summary

Endoscopic retrograde cholangiopancreatography (ERCP) is slightly more challenging with duodenal diverticula. However, endoscopic sphincterotomy success and safety remain comparable for patients with or without diverticula.

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Area of Science:

  • Gastroenterology
  • Endoscopic procedures
  • Digestive system anatomy

Background:

  • Periampullary diverticula are common findings during ERCP.
  • The impact of duodenal diverticula on ERCP outcomes is not well-established.

Purpose of the Study:

  • To compare the difficulty and success rates of ERCP and endoscopic sphincterotomy in patients with and without periampullary diverticula.
  • To assess the safety and efficacy of sphincterotomy in patients with diverticula.

Main Methods:

  • Retrospective review of 2458 prospectively reported ERCPs.
  • Comparison of outcomes between patients with periampullary diverticula (n=308) and those without (n=2150).
  • Analysis of diagnostic cholangiography success, sphincterotomy success, morbidity, and mortality.

Main Results:

  • Diagnostic cholangiography success was slightly lower in the diverticula group (94.2% vs 96.7%).
  • Overall endoscopic sphincterotomy success was comparable (95.2% vs 98.0%), with similar morbidity and mortality rates.
  • Stone clearance in choledocholithiasis was equally successful in both groups.
  • Medium-term complications were low and similar between groups (1.4% vs 0.7%).

Conclusions:

  • Diagnostic cholangiography is more challenging with periampullary diverticula.
  • Endoscopic sphincterotomy can be performed as successfully and safely in patients with or without diverticula, provided successful cholangiography is achieved.