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Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
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Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

14
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

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A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
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Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

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A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

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Endovascular stroke therapy.

Jonathan Birns1, Sam Qureshi1, Ruoling Chen2

  • 1Department of Ageing & Health, St Thomas' Hospital, London, United Kingdom; Department of Stroke Medicine, King's College Hospital, London, United Kingdom.

European Journal of Internal Medicine
|July 19, 2014
PubMed
Summary
This summary is machine-generated.

Endovascular treatments for ischemic stroke show promise, but clinical success hinges on rapid intervention. Combined therapies are emerging as a focus for future research in acute cerebral ischemia.

Keywords:
Clot retrievalEndovascularIntra-arterialStrokeThrombolysis

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Area of Science:

  • Neurointerventional Radiology
  • Cerebrovascular Diseases

Background:

  • Intravenous thrombolysis is a key treatment for ischemic stroke.
  • Neurointerventional radiology offers advanced endovascular treatment options.

Purpose of the Study:

  • To review endovascular therapeutic options for ischemic stroke.
  • To examine the evidence base for these endovascular treatments.

Main Methods:

  • Review of available endovascular therapeutic options.
  • Analysis of evidence from initial studies and recent randomized trials.

Main Results:

  • Early studies showed endovascular treatments improved recanalization and neurological outcomes.
  • Recent trials indicate that recanalization does not always translate to clinical success, with time-to-treatment being critical.

Conclusions:

  • Combined therapies (IV and intra-arterial thrombolysis with clot retrieval) are being developed.
  • Further research is needed to optimize acute cerebral ischemia treatment.