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Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis

Chang-Ching Wei1, Jeng-Dau Tsai, Cheng-Li Lin

  • 1Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan.

Pediatric Nephrology (Berlin, Germany)
|July 19, 2014
PubMed

Insights

Children with atopic dermatitis (AD) have a doubled risk of developing idiopathic nephrotic syndrome (INS). This risk is higher in females and increases with AD severity and frequency of medical visits.

Area of Science:

  • Pediatric Nephrology
  • Dermatology
  • Epidemiology

Background:

  • Previous studies suggest a link between atopic diathesis and idiopathic nephrotic syndrome (INS).
  • A large-scale population cohort study was needed to clarify the relationship between atopic dermatitis (AD) and INS.

Purpose of the Study:

  • To investigate the incidence and risk of idiopathic nephrotic syndrome (INS) in children with atopic dermatitis (AD).

Main Methods:

  • A population-based cohort study using Taiwanese claims data from 1998-2007.
  • 192,295 children with newly diagnosed AD were compared to 769,169 matched controls.
  • Incidence rates and hazard ratios (HRs) for INS were calculated.

Main Results:

  • Children with AD had a 2-fold higher incidence of INS compared to controls (7.20 vs. 3.60 per 100,000 person-years).
  • The HR for INS increased with age, was higher in females, and correlated with AD severity (more medical visits).
  • The risk of INS significantly increased within 5 years after AD onset.

Conclusions:

  • Children diagnosed with atopic dermatitis exhibit a significantly higher incidence and risk of developing idiopathic nephrotic syndrome.
  • The risk of INS in children with AD escalates with disease severity and is particularly pronounced in the initial years post-diagnosis.
Abstract

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