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Updated: Apr 26, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Neurovascular coupling in pregnancy and the risk of preeclampsia
Wibke G Janzarik1, Renata Ehmann1, Elena Ehlers1
1From the Departments of Neurology (W.G.J., R.E., E.E., C.W., M.R.), Pediatrics and Adolescent Medicine (W.G.J.), and Obstetrics and Gynecology (S.M., B.G., H.P.), University of Freiburg, Freiburg, Germany; and Department of Statistics, University of Ulm, Ulm, Germany (A.A.).
Background And Purpose:
This study investigated whether a short testing of neurovascular coupling during midterm pregnancy could identify women at risk for subsequent preeclampsia.
Methods:
Transcranial Doppler sonography of the posterior cerebral artery during a brief visual stimulation was analyzed in 68 women at midterm pregnancy, the primary clinical end point was preeclampsia.
Results:
Women with bilateral notching of the uterine arteries showed an exaggerated visually evoked blood flow increase and longer time-to-peak. Neurovascular coupling was not significantly associated with the occurrence of preeclampsia.
Conclusions:
Neurovascular coupling was altered in women with impaired uteroplacentar vasoregulation but not a significant predictor of preeclampsia.
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