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Updated: Apr 26, 2026

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Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
Published on: September 25, 2009
13.1K
The MitraClip experience and future percutaneous mitral valve therapies
Paul Bhamra-Ariza1, David W M Muller1
1Cardiology Dept, St Vincent's Hospital, Victoria St, Darlinghurst, NSW 2010, Australia.
Heart, Lung & Circulation
|July 19, 2014
Summary
Severe mitral regurgitation (MR) affects many globally. Percutaneous mitral valve repair, like the MitraClip system, offers a less invasive treatment option for high-risk patients, improving outcomes and reducing procedure times.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Medical Devices
Background:
- Mitral regurgitation (MR) is the most prevalent heart valve abnormality worldwide.
- Increasing elderly population will likely increase the prevalence of severe MR.
- High-risk patients often ineligible for surgery need alternative treatment options.
Purpose of the Study:
- To review the literature on the MitraClip system for treating severe MR.
- To discuss novel percutaneous techniques for severe MR management.
- To highlight the benefits of transcatheter mitral valve repair in specific patient groups.
Main Methods:
- Review of existing literature on MitraClip and other percutaneous mitral repair devices.
- Analysis of procedural outcomes, including procedural time and MR reduction.
- Focus on patient selection for percutaneous interventions.
Main Results:
- The MitraClip system has been used in over 10,000 patients.
- Procedural times for MitraClip have significantly decreased.
- A growing number of patients achieve ≤ grade 2+ MR post-procedure.
Conclusions:
- Percutaneous mitral valve repair, exemplified by MitraClip, is a viable option for severe MR.
- It offers a less invasive alternative for elderly and high-risk surgical patients.
- Ongoing development of percutaneous techniques promises further advancements in MR treatment.

