Related Experiment Video
Updated: Apr 26, 2026

Monitoring Astrocyte Reactivity and Proliferation in Vitro Under Ischemic-Like Conditions
Published on: October 21, 2017
[Current conceptions about astrocyte reactivity in schizophrenia].
Schizophrenia research shows that while astrogliosis is absent, astrocytes are actively involved in the disease, potentially linked to immune system changes.
Area of Science:
- Neuroscience
- Psychiatry
- Cell Biology
Context:
- Schizophrenia is a complex psychiatric disorder with debated neuropathological underpinnings.
- Astrocytes, critical glial cells, have been implicated in various neurological conditions.
Purpose:
- To review the role of astrocytes in schizophrenia based on recent literature.
- To examine astrocyte reactivity, pathology, markers, and the impact of neuroleptics.
Summary:
- Recent studies indicate no astrogliosis in schizophrenic brains.
- Evidence suggests active astrocyte involvement in schizophrenia's pathology.
- Astrocyte activation in schizophrenia may be linked to immune system alterations.
Impact:
- This review clarifies the role of astrocytes in schizophrenia, challenging previous assumptions about astrogliosis.
- Findings suggest astrocytes as potential therapeutic targets, particularly concerning immune modulation in schizophrenia.
More Related Videos
08:04Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
Published on: November 19, 2020
05:14Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
Published on: September 8, 2021
Related Concept Videos
Psychological and Sociocultural Causes of Schizophrenia
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Excitatory and Inhibitory Effects of Neurotransmitters
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...