Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

7.2K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
7.2K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.4K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.4K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.3K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.3K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.4K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.4K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

7.2K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
7.2K
Inflammation01:38

Inflammation

46.2K
Overview
46.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Atherosclerotic Cardiovascular Disease and Cancer.

Immunological reviews·2026
Same author

Fate-mapping infiltrating monocytes following experimental myocardial infarction revealsdifferentiation trajectories in the infarcted heart.

The Journal of clinical investigation·2026
Same author

CSF1R regulates monocyte subset differentiation and intracellular metabolism.

Nature communications·2026
Same author

Stress Granule Coarsening Is a Pathological Inflection Point for Cardiac Electrophysiological Dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Novel mouse models for perianal fistulizing Crohn's disease reveal therapeutic value of interferon-γ antagonists.

bioRxiv : the preprint server for biology·2026
Same author

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026

Related Experiment Video

Updated: Apr 26, 2026

Bone Marrow-derived Macrophage Production
07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

74.0K

Origin and functions of tissue macrophages.

Slava Epelman1, Kory J Lavine1, Gwendalyn J Randolph2

  • 1Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Immunity
|July 19, 2014
PubMed
Summary

Most adult tissue macrophages develop during embryonic development, not from circulating monocytes. This study explores the distinct roles of these embryonically-derived macrophages versus monocyte-derived ones in tissue homeostasis and inflammation.

More Related Videos

Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury
05:40

Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury

Published on: November 17, 2023

2.2K
Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Published on: April 29, 2015

36.9K

Related Experiment Videos

Last Updated: Apr 26, 2026

Bone Marrow-derived Macrophage Production
07:06

Bone Marrow-derived Macrophage Production

Published on: November 22, 2013

74.0K
Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury
05:40

Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury

Published on: November 17, 2023

2.2K
Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation
08:21

Isolation of Murine Peritoneal Macrophages to Carry Out Gene Expression Analysis Upon Toll-like Receptors Stimulation

Published on: April 29, 2015

36.9K

Area of Science:

  • Immunology
  • Cell Biology
  • Tissue Homeostasis

Background:

  • Macrophages are crucial for tissue homeostasis and disease.
  • Recent findings indicate most adult tissue macrophages originate from embryonic development, challenging the monocyte origin theory.
  • The functional roles of embryonically-derived versus monocyte-derived macrophages remain unclear.

Purpose of the Study:

  • To investigate the functional differences between embryonically-derived and monocyte-derived macrophages.
  • To explore the impact of tissue origin versus ontological origin on macrophage function.
  • To re-evaluate the role of circulating monocytes in inflammation and tissue repair.

Main Methods:

  • Utilizing advanced tools for identifying complex origins of tissue macrophages.
  • Comparative analysis of macrophage populations in different tissue environments.
  • Investigating macrophage behavior during both steady-state and inflammatory conditions.

Main Results:

  • Demonstrated distinct functional properties of macrophages based on their embryonic or monocyte origin.
  • Highlighted the significant influence of tissue microenvironment on macrophage specialization.
  • Characterized the differential roles of classical and nonclassical monocytes in patrolling and inflammatory responses.

Conclusions:

  • Embryonically-derived macrophages play distinct roles in maintaining tissue homeostasis.
  • Ontological origin and tissue niche significantly regulate macrophage function.
  • Circulating monocytes have specific roles in surveillance and inflammation, differentiating into distinct macrophage populations.