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Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

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Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
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Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

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Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
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Seizures l: Introduction01:20

Seizures l: Introduction

33
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
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Related Experiment Video

Updated: Apr 26, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
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Lacosamide-induced rash.

Mohamad Z Koubeissi1, Marta Vismer1, Alison Ehrlich2

  • 1Department of Neurology.

Epileptic Disorders : International Epilepsy Journal with Videotape
|July 19, 2014
PubMed
Summary

Lacosamide, an anti-seizure drug, can cause rare skin reactions like diffuse eruptions. Discontinuation of the medication and supportive care led to resolution in a patient with epilepsy.

Area of Science:

  • Neurology
  • Dermatology
  • Pharmacology

Background:

  • Anti-seizure medications (ASMs) are known to cause cutaneous adverse events.
  • Hypersensitivity reactions are a significant concern with many ASMs.
  • Lacosamide, a newer ASM, has a novel mechanism of action and limited reported skin side effects.

Observation:

  • A case study involving a patient with a history of epilepsy is presented.
  • The patient developed a diffuse skin eruption shortly after starting lacosamide treatment.
  • This adverse event was observed despite lacosamide's generally favorable side effect profile.

Findings:

  • Cutaneous eruption is a potential, albeit rare, side effect of lacosamide.
  • The patient's rash resolved completely after discontinuing lacosamide.
Keywords:
allergiclacosamiderash

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  • Treatment with antihistamines and steroids facilitated the resolution of the skin eruption.

    • Implications:

    • This case highlights the importance of considering lacosamide-induced hypersensitivity in patients presenting with new skin rashes.
    • Clinicians should be vigilant for cutaneous side effects even with newer ASMs.
    • Further pharmacovigilance is warranted to fully characterize the dermatological safety profile of lacosamide.