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Updated: Apr 26, 2026

Dual Immunofluorescence of γH2AX and 53BP1 in Human Peripheral Lymphocytes
Published on: July 14, 2023
Salmonella typhimurium with γ-radiation induced H2AX phosphorylation and apoptosis in melanoma
Won Suck Yoon1, Sinyeon Kim, Sungchul Seo
1a School of Life Sciences and Biotechnology, Korea University , Seoul , Republic of Korea.
Abstract:
To investigate the combinatorial effects using Salmonella and γ-radiation, the Salmonella typhimurium infection in combination with γ-radiation was investigated on melanoma. We showed that ROS expression and H2AX phosphorylation increased during stress by γ-radiation irrespective of Salmonella infection, inducing apoptosis by caspase-3 and bcl2 in tumor cells. In addition, tumor growth was suppressed by this combinatory therapy suggesting candidates for radiation therapy against melanoma.
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