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Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome

X H Wang1, S Q Liu2, Y L Wang2

  • 1Department of Cardiology, Liaocheng People's Hospital, Liaocheng, Shandong, China xiaohuawangcn@163.com.

Genetics and Molecular Research : GMR
|July 19, 2014
PubMed

Insights

Serum high-sensitivity C-reactive protein (hs-CRP) and Interleukin-6 (IL-6) are elevated in acute coronary syndrome (ACS). These inflammatory markers correlate positively, aiding in assessing plaque stability and ACS prognosis.

Area of Science:

  • Cardiology
  • Biochemistry
  • Inflammation Research

Background:

  • Serum high-sensitivity C-reactive protein (hs-CRP) indicates inflammation and plaque formation.
  • Interleukin-6 (IL-6) is an inflammatory marker linked to atherosclerosis and plaque rupture.
  • Understanding the relationship between hs-CRP and IL-6 in acute coronary syndrome (ACS) is crucial.

Purpose of the Study:

  • To investigate the correlation between hs-CRP and IL-6 levels in patients with ACS.
  • To evaluate the diagnostic and prognostic value of these markers in ACS.

Main Methods:

  • Study included 60 ACS patients (33 acute myocardial infarction, 27 unstable angina pectoris), 45 stable angina pectoris patients, and 45 healthy controls.
  • Serum hs-CRP was measured using immune turbidimetric method.
  • Serum IL-6 levels were determined by enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • hs-CRP and IL-6 concentrations were significantly higher in acute myocardial infarction (AMI) and unstable angina pectoris (UAP) groups compared to stable angina pectoris (SAP) and healthy groups (P<0.01).
  • AMI group showed significantly higher levels than the UAP group (P<0.05).
  • A strong positive correlation (r=0.836) was observed between serum hs-CRP and IL-6 levels in ACS patients.

Conclusions:

  • Elevated hs-CRP and IL-6 levels are associated with ACS.
  • These inflammatory markers can help determine plaque stability and have prognostic relevance in ACS.
  • hs-CRP and IL-6 show significant value in the judgment of ACS prognosis.

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