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Effect of statins in preventing contrast-induced nephropathy: an updated meta-analysis

Hongzhi Xie1, Yicong Ye, Guangliang Shan

  • 1aDepartment of Cardiology, Peking Union Medical College Hospital bDepartment of Epidemiology and Statistics, School of Basic Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Coronary Artery Disease
|July 19, 2014
PubMed

Insights

Pretreatment with statins before angiography significantly reduces the risk of contrast-induced nephropathy (CIN). This meta-analysis confirms statins

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Conflicting results exist regarding statins' efficacy in preventing contrast-induced nephropathy (CIN).
  • CIN is a significant complication following radiocontrast procedures.

Purpose of the Study:

  • To conduct an updated meta-analysis evaluating statin pretreatment for CIN prevention.
  • To assess the impact of statins on CIN and associated adverse clinical events.

Main Methods:

  • Systematic database searches of MEDLINE, EMBASE, and Cochrane Central Register.
  • Inclusion of all randomized controlled trials on statins and CIN.
  • Meta-analysis of 17 studies involving 6323 patients.

Main Results:

  • Statin pretreatment significantly reduced CIN risk (RR 0.50, P<0.001).
  • Lower postprocedural serum creatinine levels observed with statins (WMD -0.05 mg/dl, P=0.005).
  • Trends towards reduced risks of renal replacement therapy and all-cause death within 30 days.

Conclusions:

  • Statin pretreatment is effective in preventing CIN.
  • Statins may lower the risk of adverse clinical events post-angiography.
  • Optimal statin dose and duration for pretreatment require further investigation.
Abstract

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