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Improved human islet preparations using glucocorticoid and exendin-4.

Atsushi Miki1, Camillo Ricordi, Toshiyuki Yamamoto

  • 1From the *Cell Transplant Center, Diabetes Research Institute, †DeWitt Family Department of Surgery, ‡Jackson Memorial Hospital Transplant Institute, §Department of Microbiology and Immunology, and ∥Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL; and ¶Department of Surgery and Medicine, University of California Irvine, Orange, CA.

Pancreas
|July 19, 2014
PubMed
Summary

Methylprednisolone (MP) and Exendin-4 (EX) improve human islet cell survival during culture. MP reduces inflammatory cytokines, while EX preserves insulin secretion, suggesting their combined use enhances islets for transplantation.

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