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High-throughput Gene Tagging in Trypanosoma brucei

High-throughput Gene Tagging in Trypanosoma brucei

Published on: August 12, 2016

Trypanosoma brucei: meet the system.

Fiona Achcar¹, Eduard J Kerkhoven², Michael P Barrett¹

¹Wellcome Trust Centre of Molecular Parasitology and Glasgow Polyomics, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, United Kingdom.

Current Opinion in Microbiology

|July 19, 2014

Summary

African trypanosomes cause significant diseases. This study uses systems biology to analyze the parasite

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Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis

Published on: May 18, 2016

Area of Science:

Parasitology
Molecular Biology
Biochemistry

Background:

African trypanosomes cause devastating diseases in humans and animals.
These parasites possess unique biochemical and genetic features.
Understanding these peculiarities is crucial for disease control.

Purpose of the Study:

To integrate diverse datasets for a systems-level understanding of African trypanosomes.
To analyze the parasite's biochemical physiology as an integrated system.

Main Methods:

Data collection across various aspects of trypanosome physiology.
Analysis of genetic expression mechanisms (nuclear and mitochondrial).
Investigation of enzyme subcellular localization.

Main Results:

Identification of unconventional gene expression pathways.
Characterization of unusual enzyme localizations within the parasite.
Compilation of a comprehensive dataset for systems biology analysis.

Conclusions:

Systems biology approaches are vital for contextualizing complex biological data.
A holistic view of trypanosome physiology is emerging.
This integrated analysis advances our understanding of these pathogenic parasites.