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Subtype of mild cognitive impairment in elderly patients with essential tremor

In-Seok Park1, Yoon-Sang Oh, Kwang-Soo Lee

  • 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul St Mary's Hospital, Seoul, South Korea.

Alzheimer Disease and Associated Disorders
|July 19, 2014
PubMed
Abstract

Insights

Essential tremor (ET) is linked to mild cognitive impairment (MCI), especially the nonamnestic subtype. This suggests cognitive changes in ET may differ from Alzheimer's disease pathology.

Area of Science:

  • Neurology
  • Neuropsychology
  • Cognitive Science

Background:

  • Essential tremor (ET) is frequently associated with mild cognitive impairments (MCIs).
  • Different MCI subtypes may indicate distinct underlying pathologies, with amnestic MCI often linked to Alzheimer's disease.
  • Understanding MCI subtypes in ET is crucial for differentiating cognitive changes.

Purpose of the Study:

  • To investigate if the subtype of mild cognitive impairment (MCI) in patients with essential tremor (ET) differs from that in patients without ET.
  • To compare cognitive profiles between MCI patients with ET (MCI-ET+) and without ET (MCI-ET-) attending a memory clinic.

Main Methods:

  • A case-control study design was employed.
  • Cognitive status was assessed using neuropsychological testing.
  • MCI patients were stratified into amnestic/nonamnestic and single-domain/multidomain MCI groups.

Main Results:

  • MCI was diagnosed in 48.4% of ET+ patients and 55.6% of ET- patients.
  • A significant difference in MCI subtypes was observed: nonamnestic MCI was more frequent in the ET+ group (55.6%) compared to the ET- group (72.3% amnestic MCI).
  • Patients without ET (MCI-ET-) exhibited more severe deficits in verbal and visuospatial memory than those with ET (MCI-ET+).

Conclusions:

  • Essential tremor is associated with mild cognitive impairment, particularly the nonamnestic subtype.
  • The findings suggest that cognitive alterations in ET may stem from a different pathological process than that seen in Alzheimer's disease.

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