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Evaluation of bone metastases from breast cancer by bone scintigraphy and positron emission tomography/computed
Ary O Pires1, Umbelina S Borges1, Pedro V Lopes-Costa1
1Department of Gynecology, Mastology Division, Federal University of Piauí, Teresina, Piauí, Brazil.
Objective:
The aim of this study was to compare bone scintigraphy (BS) and positron emission tomography/computed tomography (PET/CT) for the detection of bone metastases from breast cancer.
Study Design:
Twenty patients with breast cancer and bone pain were submitted to both bone scintigraphy and 18-F-fluorodeoxyglucose PET/CT imaging between July 2012 and June 2013. Scintigraphy was performed following an intravenous injection of technetium-99m-methylene diphosphonate (99mTc-MDP) around 10 days before the PET/CT scan, performed using an intravenous injection of 18-F-fluorodeoxyglucose followed by whole-body computed tomography (CT) to characterize metastases by both methods. Student's t-test for paired samples was used in the comparative data analysis, with significance at p<0.05.
Results:
CT identified 429 metastatic implants in the 20 patients, with scintigraphy showing 244 of these lesions (57%) and PET/CT showing 307 (72%); however, there was no statistically significant difference between the mean number of lesions detected per patient with the two imaging modalities (p=0.367).
Conclusion:
In the present study, no difference was found between PET/CT and bone scintigraphy in the detection of bone metastases from breast cancer.
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