Related Experiment Video For biobehavioral
Updated: Apr 26, 2026

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
Published on: October 21, 2017
Shared symptoms and putative biological mechanisms in chronic liver disease: implications for biobehavioral research
Victoria Menzies1, Nancy Jallo2, Patricia Kinser2
1Virginia Commonwealth University School of Nursing, Richmond, VA, USA vsmenzies@vcu.edu.
Abstract:
Liver disease affects over 25 million people in the United States and, despite advances in medical management resulting in increased survival, a majority of these individuals report multiple co-occurring symptoms that severely impair functioning and quality of life. The purpose of this review is to (1) propose defining these co-occurring symptoms as a symptom cluster of chronic liver disease (CLD), (2) discuss putative underlying biological mechanisms related to CLD, including the liver-gut-brain axis and influence of the microbiome, and (3) discuss the implications for biobehavioral research in this patient population. Biobehavioral research focusing on the interrelated, and possibly synergistic, mechanisms of these symptoms may lead to the development and testing of targeted symptom management interventions for improving function and quality of life in this growing patient population.
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