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Tract based spatial statistics in multiple system atrophy: a comparison between clinical subtypes.

Li Ji1, Donglin Zhu1, Chaoyong Xiao2

  • 1Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing 210029, PR China.

Parkinsonism & Related Disorders
|July 20, 2014
PubMed
Summary
This summary is machine-generated.

This study reveals shared white matter changes in both Multiple System Atrophy-Cerebellar (MSA-C) and Multiple System Atrophy-Parkinsonian (MSA-P) variants, with distinct differences in the superior longitudinal fasciculus potentially impacting disease progression.

Keywords:
Diffusion tensor imageMSA variantsSuperior longitudinal fasciculusTract based spatial statistic analysisWhite matter

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Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Research

Background:

  • Multiple System Atrophy (MSA) presents in two main variants: MSA-Cerebellar (MSA-C) and MSA-Parkinsonian (MSA-P).
  • Understanding the micro-structural white matter differences and similarities between these variants is crucial for diagnosis and prognosis.

Purpose of the Study:

  • To investigate micro-structural white matter similarities and differences between MSA-C and MSA-P using tract-based spatial statistics (TBSS).
  • To correlate white matter abnormalities with clinical severity in MSA patients.

Main Methods:

  • Diffusion tensor imaging (DTI) data were acquired from 10 MSA-P, 15 MSA-C patients, and 15 controls.
  • Tract-based spatial statistics (TBSS) was employed for pairwise comparisons of fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD).
  • Regions of interest (ROIs) with diffusivity abnormalities were analyzed for correlations with clinical severity.

Main Results:

  • Both MSA-C and MSA-P showed decreased FA in the bilateral corticospinal tract (CST) and right anterior thalamic radiation (ATR).
  • Increased radial diffusivity (RD) was observed in the bilateral CST for both variants, correlating with clinical severity.
  • Higher axial diffusivity (AD) in the superior longitudinal fasciculus (SLF) was found in MSA-P compared to MSA-C.

Conclusions:

  • MSA-C and MSA-P share common white matter diffusivity abnormalities in the CST and ATR.
  • Elevated SLF AD in MSA-P may contribute to more rapid functional decline compared to MSA-C.