Related Experiment Video
Updated: Apr 26, 2026
Preterm EEG: A Multimodal Neurophysiological Protocol
Published on: February 18, 2012
Evaluation of somatosensory cortical processing in extremely preterm infants at term with MEG and EEG
Päivi Nevalainen1, Petri Rahkonen2, Elina Pihko3
1BioMag Laboratory, Hospital District of Helsinki and Uusimaa, HUS Medical Imaging Center, Helsinki University Central Hospital (HUCH), Helsinki, Finland; Department of Clinical Neurophysiology, Children's Hospital, HUS Medical Imaging Center, HUCH, University of Helsinki, Helsinki, Finland.
Objective:
Prior studies on extremely preterm infants have reported long-term prognostic value of absent secondary somatosensory cortex (SII) responses in magnetoencephalography (MEG) at term. The present work (i) further examines the potential added value of SII responses in neonatal neurological evaluation of preterm infants, and (ii) tests whether SII responses are detectable in routine neonatal electroencephalogram complemented with median nerve stimulation (EEG-SEP).
Methods:
Altogether 29 infants born <28 gestational weeks underwent MEG, MRI, and neonatal neurological examination at term age, and Hempel neurological examination at 2-years corrected age. Term-age EEG-SEP was available for seven infants.
Results:
While in neonatal neurological examination severely abnormal finding predicted unfavorable outcome in 2/2 infants, outcome was unfavorable also in 3/9 (33%) moderately abnormal and in 5/18 (28%) mildly abnormal/normal infants. Of these eight infants four had unilaterally absent SII responses in MEG, compared with only two of the 24 infants with favorable outcome. Furthermore, SII responses (when present in MEG) were also usually detectable in EEG-SEP.
Conclusions:
Complementing clinical EEG recording with SEP holds promise for valuable extension of neonatal neurophysiological assessment.
Significance:
Multimodal study of EEG and sensory evoked responses is informative, safe, and cheap, and it can be readily performed at bedside.
