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Phragmalin-type limonoids with NF-κB inhibition from Chukrasia tabularis var. velutina
Feng Zhang1, Chuan-Rui Zhang2, Xia Tao3
1Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, PR China; State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
Abstract:
Chemical investigation on Chukrasia tabularis var. velutina led to the identification of eight new phragmalin-type limonoids (1-8), as well as 20 known analogues. Compounds 1-4 are a rare class of C-15-acyl phragmalin-type limonoids, and particularly compounds 2-4 also possess a δ-lactone ring formed between C-16 and C-30. All the isolates were evaluated for inhibitory effects on NF-κB production, and four of which showed significant inhibitions.
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