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Upper Extremity Multifocal Neuropathy in a 10-Year-Old Boy Associated With NS6S Disaccharide Antibodies
Frederick Edelman1, Elie Naddaf2, Andrew J Waclawik3
1Child Neurology Division, Department of Neurology, University of Wisconsin Hospital and Clinics, Madison, WI, USA Edelman@neurology.wisc.edu.
Abstract:
We present a 10-year-old boy with a predominantly motor multifocal neuropathy with demyelinating and axonal changes with sensory involvement, affecting only one upper extremity. Laboratory studies revealed an elevated titer of immunoglobulin M (IgM) antibodies against the NS6S antigen. He responded to treatment with high dose intravenous immunoglobulins. Focal or multifocal immune-mediated neuropathies are not common in children and may be underdiagnosed.
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