Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

14
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
14
Vascular Spasm01:16

Vascular Spasm

4.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.8K
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

1.8K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.8K
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

15
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
15
Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

14
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
14
Acute Inflammation II: Local and Systemic Effects01:25

Acute Inflammation II: Local and Systemic Effects

45
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
45

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Training load influences gut microbiome of highly trained rowing athletes.

Journal of the International Society of Sports Nutrition·2025
Same author

Evaluation of a portable, lightweight modular system to deliver high inspired oxygen to trauma casualties without the use of pressurised cylinders.

BMJ military health·2024
Same author

Optimisation of mitochondrial function as a novel target for resuscitation in haemorrhagic shock: a systematic review.

BMJ military health·2023
Same author

Design and testing of the safety of the SARUS-CPR hood for novice resuscitators.

Scottish medical journal·2022
Same author

COVID-19 pandemic-related impact on two-week wait window for clinic visits in dermatology departments-results of pre-visit image referrals.

Dermatology online journal·2021
Same author

Measurement of <math></math> production with the hadronically decaying boson reconstructed as one or two jets in <i>pp</i> collisions at <math> </math> with ATLAS, and constraints on anomalous gauge couplings.

The European physical journal. C, Particles and fields·2020
Same journal

Audit of procedural sedation complications using a novel digital application.

British journal of anaesthesia·2026
Same journal

Social deprivation and morbidity and mortality after surgery. Comment on Br J Anaesth 2025; 135: 1193-1202.

British journal of anaesthesia·2026
Same journal

Single-dose intraoperative methadone and QTc interval: a prospective observational cohort investigation.

British journal of anaesthesia·2026
Same journal

Postoperative outcomes in older patients with postoperative delirium in the UK: timing of postoperative delirium screening in the SNAP-3 study. Comment on Br J Anaesth 2026; 136: 1578-87.

British journal of anaesthesia·2026
Same journal

Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia.

British journal of anaesthesia·2026
Same journal

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis.

British journal of anaesthesia·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.2K

Haemodynamic changes in trauma.

E Kirkman1, S Watts2

  • 1Biomedical Sciences Department, Defence Science and Technology Laboratory, Porton Down, Salisbury, UK ekirkman@dstl.gov.uk.

British Journal of Anaesthesia
|July 20, 2014
PubMed
Summary
This summary is machine-generated.

Trauma

Keywords:
haemodynamicswounds and injuries

More Related Videos

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

27.7K
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries
08:21

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Published on: April 1, 2019

8.6K

Related Experiment Videos

Last Updated: Apr 26, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.2K
Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

27.7K
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries
08:21

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Published on: April 1, 2019

8.6K

Area of Science:

  • Trauma resuscitation
  • Hemodynamic response to injury
  • Physiology of shock

Background:

  • Trauma is a leading cause of death in developed countries.
  • Hemodynamic response is critical for survival and treatment efficacy.
  • Trauma involves insults like hemorrhage, tissue injury, and blast exposure.

Purpose of the Study:

  • To discuss hemodynamic responses to trauma-related insults.
  • To explore the impact of different resuscitation strategies.
  • To examine the role of morphine in trauma response.

Main Methods:

  • Review of hemodynamic responses to hemorrhage, tissue injury, and blast.
  • Analysis of biphasic hemodynamic response to simple hemorrhage.
  • Discussion of alternative resuscitation strategies like 'hybrid resuscitation'.

Main Results:

  • Simple hemorrhage elicits a biphasic hemodynamic response (Phase 1 and Phase 2).
  • Tissue injury can attenuate Phase 2, leading to detrimental redistribution.
  • Blast exposure augments Phase 2; hypoxemia complicates resuscitation.

Conclusions:

  • Hybrid resuscitation may improve tissue perfusion after initial hypotensive resuscitation.
  • Morphine's effect on Phase 2 and outcome varies by species; human impact is under investigation.
  • Understanding hemodynamic responses is key to optimizing trauma patient care.