[Study on process and principle of lactose grinding modification to decrease hygroscopic of Rhodiolae Crenulatae...

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Rhodiolae Crenulatae Radix et Rhizoma extract exhibits high hygroscopicity, posing challenges for its application.
• Lactose is commonly used as an excipient and modifier in pharmaceutical formulations.

Purpose of the Study:

• To investigate the effect of grinding modification using lactose on the hygroscopicity of Rhodiolae Crenulatae Radix et Rhizoma extract.
• To analyze the physical and chemical properties of the modified extract.

Main Methods:

• Grinding modification of Rhodiolae Crenulatae Radix et Rhizoma extract with lactose.
• Analysis of particle size distribution, scanning electron microscopy (SEM), infrared spectroscopy (IR), and surface properties.
• Measurement of hygroscopic properties including initial velocity, acceleration, and critical relative humidity.

Main Results:

• The modified extract exhibited significantly reduced hygroscopic initial velocity, acceleration, and critical relative humidity compared to the original extract and a simple mixture.
• Grinding modification resulted in a finer particle size distribution and altered microstructure of the extract.
• Infrared spectroscopy and surface properties of the modified extract were similar to those of lactose.

Conclusions:

• Grinding Rhodiolae Crenulatae Radix et Rhizoma extract with lactose effectively reduces its hygroscopicity.
• The primary mechanism involves the adhesion of lactose particles to the extract surface, thereby decreasing moisture uptake.