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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Related Experiment Video

Updated: Apr 26, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Microscopic colitis: a review.

A Farrukh1, J F Mayberry

  • 1Digestive Disease Centre, University Hospitals of Leicester, Leicester, UK.

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
|July 22, 2014
PubMed
Summary
This summary is machine-generated.

Microscopic colitis, including collagenous colitis and lymphocytic colitis, is increasingly diagnosed, particularly in older women. Current treatments rely on limited evidence, highlighting the need for more research.

Keywords:
aetiology treatmentepidemiologymicroscopic colitis

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Area of Science:

  • Gastroenterology
  • Histopathology
  • Epidemiology

Background:

  • Microscopic colitis, encompassing collagenous colitis and lymphocytic colitis, is diagnosed with increasing frequency.
  • While typically benign, it can lead to severe complications.

Purpose of the Study:

  • To evaluate demographic factors associated with microscopic colitis.
  • To systematically assess current treatment options for microscopic colitis.

Main Methods:

  • A comprehensive literature search was conducted on PubMed and Google Scholar.
  • Publications up to December 2013 were reviewed, identifying 248 relevant articles on microscopic colitis, collagenous colitis, and lymphocytic colitis.

Main Results:

  • Microscopic colitis presents with common symptoms but distinct histopathology for collagenous and lymphocytic subtypes.
  • Peak incidence occurs between 60-70 years with a female predominance.
  • Associations with autoimmune diseases and certain medications (NSAIDs, PPIs) are noted; incidence is rising.

Conclusions:

  • The review synthesizes current knowledge on microscopic colitis definition, subtypes, epidemiology, and etiology.
  • Treatment efficacy is largely based on limited trials and anecdotal evidence, with budesonide being a primary option.
  • Further epidemiological research and established long-term follow-up protocols are needed.