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Published on: June 29, 2022
Foreign body giant cell reaction to tarSys™ xenograft
William R Munday1, Zachary Klett, Jennifer M McNiff
1Yale-New Haven Hospital, Department of Pathology, New Haven, CT, USA.
Objective:
A foreign body giant cell (FBGC) reaction may occur in response to implanted xenogenic biomaterials. Here we report a FBGC reaction to the recently introduced xenogenic biomaterial, tarSys™, used for correction of lower eyelid retraction.
Method:
A retrospective chart review of two patients with FBGC reaction to tarSys™ implantation was performed.
Results:
Two patients (aged 51, 58 year) with lower eyelid retraction underwent surgical implantation of tarSys™ spacer grafts for correction. Both patients subsequently experienced chronic swelling requiring graft removal. Examination of the specimens showed a palisading FBGC reaction around acellular pink fibrillar material.
Conclusion:
A FBGC reaction may follow implantation of the tarSys™ xenograft.
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