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Updated: Apr 26, 2026
Application of End-to-end Anastomosis in Robotic Central Pancreatectomy
Published on: June 2, 2018
Prognostic factors in 151 patients with surgically resected non-functioning pancreatic neuroendocrine tumours
Ki Byung Song1, Song Cheol Kim1, Ji Hoon Kim2
1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, South Korea.
Background:
Recently, non-functioning pancreatic neuroendocrine tumors (NF-PNETs) are increasing. It is important to know about the prognostic factors and long-term survival rates in patients with NF-PNET for the management of these diseases.
Methods:
We retrospectively analysed the records of 151 patients with NF-PNET who had pancreatic resection between January 1995 and December 2010.
Result:
The 10-year overall survival, disease-specific survival and disease-free survival rate of the patients who underwent surgery for NF-PNET were 72.6%, 85.1% and 57.2% respectively. The three staging systems (2004 World Health Organization classification, 2006 European Neuroendocrine Tumor Society stages and 2010 grading system) showed comparable prognostic relevance in disease-specific survival of patients with resected NF-PNETs. Lymph nodes metastasis, high Ki-67 index and mitotic rate were the independent poor prognostic factors for disease-specific survival in the patients with surgically resected NF-PNET on multivariate analysis.
Conclusion:
We suggested that the three staging systems accurately reflect the prognosis in disease-specific survival of patients with resected NF-PNETs. Presence of lymph nodes metastases and high Ki-67 index and mitotic rate were the independent poor prognostic factors after resection of NF-PNET.
