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Updated: Apr 26, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Correlation between Migraine Severity and Cholesterol Levels.

Claudio Tana1,2, Francesca Santilli1, Paolo Martelletti3

  • 1Department of Medicine and Science of Aging, "G. d'Annunzio" University, Chieti, Italy.

Pain Practice : the Official Journal of World Institute of Pain
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PubMed
Summary

Migraine frequency and intensity correlate with higher total and LDL cholesterol. Migraine prophylaxis treatment significantly reduced these lipid levels, suggesting a link between headache management and cardiovascular health.

Keywords:
Framingham scoreLDL cholesterolcardiovascular riskheadachemigrainetotal cholesterol

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Area of Science:

  • Neurology
  • Cardiology
  • Biochemistry

Background:

  • Migraine is linked to increased cardiovascular risk factors like hypercholesterolemia.
  • The relationship between migraine severity and serum lipid levels remains unexplored.

Purpose of the Study:

  • To investigate the association between migraine headache severity parameters and serum lipid levels.
  • To evaluate the impact of migraine prophylactic treatment on lipid profiles.

Main Methods:

  • Assessed lipid profiles in 52 migraine patients before and after 3 months of prophylactic treatment.
  • Compared lipid levels based on headache frequency (high vs. low) and intensity (high vs. low).

Main Results:

  • Higher migraine frequency and intensity were significantly associated with elevated total cholesterol (TC) and LDL cholesterol (LDL-c).
  • Successful migraine prophylaxis led to significant reductions in TC and LDL-c.
  • A direct linear correlation was observed between headache frequency/intensity and TC/LDL-c levels.

Conclusions:

  • Migraine frequency and intensity show a significant positive association with total and LDL cholesterol.
  • Migraine prophylactic treatment can lead to a significant reduction in these lipid parameters.
  • Results are preliminary due to retrospective design and small sample size; further prospective trials are needed.