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Microchimerism in the transfused obstetric population

E M Bloch1, M P Busch, T-H Lee

  • 1Blood Systems Research Institute, San Francisco, CA, USA.

Vox Sanguinis
|July 22, 2014
PubMed

Microchimerism (MC), the coexistence of allogeneic populations of cells within a host, is well described in pregnancy and blood transfusion. To date, transfusion-associated MC (TA-MC) appears unique to patients transfused after severe traumatic injury. We sought to determine whether transfusion in the peripartum period results in enduring, high-level TA-MC. We conducted a prospective cohort study of 22 women who were newly transfused within 48 h of delivery. Two subjects showed evidence of transient TA-MC; however, MC was not detected at 6 weeks and 6 months. The negative findings suggest that enduring TA-MC does not occur in this population.

Keywords:
blood transfusionchimerismperipartum

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