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Encephalitis caused by human herpesvirus-6B in pancreas-after-kidney transplantation

T Yamamoto1, Y Watarai, N Goto

  • 1Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; Department of Transplant Immunology, Nagoya University School of Medicine, Nagoya, Japan.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|July 22, 2014
PubMed

Insights

Human herpesvirus-6 (HHV-6) reactivation can cause serious neurological issues in transplant patients. This case highlights the importance of early diagnosis and treatment for HHV-6 encephalitis after pancreas transplantation.

Area of Science:

  • Virology
  • Immunology
  • Transplant Surgery

Background:

  • Human herpesvirus-6 (HHV-6) is a common childhood virus.
  • HHV-6 reactivation is a concern in immunocompromised individuals, particularly transplant recipients.
  • HHV-6 is associated with various post-transplant complications, but encephalitis after pancreas transplant is rare.

Observation:

  • A 53-year-old patient, who received a pancreas-after-kidney transplant, developed high fever and confusion three weeks post-operation.
  • The patient presented with symptoms suggestive of central nervous system involvement.

Findings:

  • The patient was diagnosed with Human herpesvirus-6 encephalitis.
  • Prompt diagnosis and management were crucial for patient survival and graft function preservation.
  • A review of existing literature on HHV-6B encephalitis in solid organ transplant recipients was conducted.

Implications:

  • This case underscores the potential for HHV-6 encephalitis in pancreas transplant recipients.
  • Early detection and intervention are critical for improving outcomes in these patients.
  • Further research into HHV-6 pathogenesis and treatment in solid organ transplant recipients is warranted.

Keywords:
HHV-6encephalitishuman herpesvirus-6Bpancreas-after-kidney transplantation

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