Recurrent miscarriage is a useful and valid clinical concept.

Area of Science:

• Reproductive Medicine
• Genetics
• Immunology

Background:

• Recurrent miscarriage (RM) has known risk factors, but its etiology is largely unknown.
• Two hypotheses exist: conception errors or maternal abnormalities causing euploid loss.
• Management strategies differ based on the underlying hypothesis.

Purpose of the Study:

• To argue that recurrent miscarriage (RM) is a specific and useful clinical concept.
• To advocate for investigations and treatments for RM patients with poor prognosis.

Main Methods:

• Review of existing hypotheses and clinical evidence regarding recurrent miscarriage.
• Argumentative approach based on clinical observations and potential management strategies.

Main Results:

• A significant subset of recurrent miscarriage patients demonstrates a poor spontaneous prognosis.
• Current management approaches are debated, with differing views on conservative versus active treatment.

Conclusions:

• Recurrent miscarriage should be considered a specific clinical entity.
• Patients with poor prognosis should undergo investigations, close surveillance, and potential treatment, ideally within clinical trials.