Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

6.2K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.2K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

4.6K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
4.6K
Skin Cancer01:30

Skin Cancer

5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

7.3K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
7.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.5K
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Driver mutations and tumor mutational burden impact stage IV melanoma survival.

Journal of the American Academy of Dermatology·2026
Same author

Use of ancillary studies in pediatric spitzoid neoplasms: A retrospective cohort study.

Journal of the American Academy of Dermatology·2026
Same author

Topical cantharidin use in dermatology: an updated review.

Dermatology online journal·2025
Same author

Clinical Utility of a Digital Dermoscopy Image-Based Artificial Intelligence Device in the Diagnosis and Management of Skin Cancer by Dermatologists.

Cancers·2024
Same author

Pseudoangiosarcoma and cutaneous collagenous vasculopathy in a patient on a Bruton's tyrosine kinase inhibitor.

JAAD case reports·2024
Same author

Exposure factors in the occurrence and development of melasma (Review).

Experimental and therapeutic medicine·2024
Same journal

M2 Macrophage-Derived ENPP2/LPA Signalling Attenuates UVB-Induced Fibroblast Photoaging via LPAR1/3.

Experimental dermatology·2026
Same journal

Human-Relevant In Vitro Skin Models: From Regulatory-Validated Platforms to Emerging Technologies for Translational Dermatology.

Experimental dermatology·2026
Same journal

Large-Scale Cohort Study on the Genetic and Phenotypic Findings of Palmoplantar Keratodermas in the Chinese Population.

Experimental dermatology·2026
Same journal

52nd Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF).

Experimental dermatology·2026
Same journal

Adverse Event Profile of Apremilast: Pharmacovigilance Study Based on FDA Adverse Event Reporting System (FAERS).

Experimental dermatology·2026
Same journal

Clinical and Immunological Characteristics of Bullous Pemphigoid Patients With Psoriasis Comorbidity: A Retrospective Study.

Experimental dermatology·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.3K

Do inflammatory pathways drive melanomagenesis?

Samantha L Schneider1, Andrew L Ross, James M Grichnik

  • 1Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA; Albert Einstein College of Medicine, Bronx, NY, USA.

Experimental Dermatology
|July 22, 2014
PubMed
Summary
This summary is machine-generated.

Inflammation promotes melanoma growth via P2X7/PANX1 channels activating the NALP3 inflammasome, caspase-1, and IL-1β. Targeting this pathway may offer new melanoma treatment strategies.

Keywords:
melanomastem celltumor stem cell

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

17.8K

Related Experiment Videos

Last Updated: Apr 26, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.3K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

8.6K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

17.8K

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Inflammation is linked to cancer development and progression.
  • Specific inflammatory pathways are increasingly implicated in melanomagenesis.
  • Anti-inflammatory drugs show mixed results in melanoma chemoprevention.

Purpose of the Study:

  • To review and model an inflammatory pathway critical for melanoma.
  • To identify potential therapeutic targets within this pathway.
  • To propose future research directions for melanoma treatment.

Main Methods:

  • Review of existing data on inflammatory pathways in melanoma.
  • Modeling of the P2X7/PANX1-NALP3 inflammasome-caspase-1-IL-1β axis.
  • Analysis of the role of IL-1β and prostaglandin E2 (PGE2) in melanoma.

Main Results:

  • P2X7 and PANX1 channels are implicated in melanoma tumor growth.
  • Activation of the NALP3 inflammasome, caspase-1, and IL-1β correlates with melanoma progression.
  • IL-1β upregulates cyclooxygenase-2, increasing inflammatory mediators like PGE2.

Conclusions:

  • The P2X7/PANX1-NALP3 inflammasome pathway is a potential driver of melanomagenesis.
  • Inhibiting components of this pathway shows promise in reducing melanoma growth.
  • Further understanding of this pathway is crucial for developing targeted melanoma therapies.