Related Experiment Video
Updated: Apr 26, 2026
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
An explained variance-based genetic risk score associated with gestational diabetes antecedent and with progression
H Cormier1, J Vigneault, V Garneau
1Department of Food Sciences and Nutrition, Laval University, Quebec City, QC, Canada; Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec City, QC, Canada.
Objective:
To determine whether an explained-variance genetic risk score (GRS), with 36 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes (T2D), is also associated with gestational diabetes mellitus (GDM), and with the progression to pre-diabetes and T2D among women with prior GDM.
Design:
A cohort study.
Setting:
Clinical investigation unit of Laval University, Quebec, Canada.
Population:
A cohort of 214 women with prior GDM and 82 controls recruited between 2009 and 2012.
Methods:
Associations between the GRS and GDM.
Main Outcomes Measures:
GDM and prevalence of pre-diabetes and T2D.
Results:
Women with prior GDM had a higher GRS compared with controls (38.6 ± 3.9, 95% CI 38.1-39.1, versus 37.4 ± 3.2, 95% CI 36.7-38.1; P < 0.0001). In women with prior GDM, the explained-variance GRS was higher for pre-diabetic women compared with women who remained normoglucotolerant at testing (1.21 ± 0.18, 95% CI 1.18-1.23, versus 1.17 ± 0.15, 95% CI 1.13-1.20; P < 0.0001). Similarly, women with T2D had a higher explained-variance GRS compared with women with prior GDM who remained normoglucotolerant (1.20 ± 0.18, 95% CI 1.14-1.25, versus 1.17 ± 0.17, 95% CI 1.13-1.20; P < 0.0001). The predictive effects of the explained-variance GRS, age, and body mass index (BMI), or the additive effects of the three variables, were tested for pre-diabetes and T2D. We observed an area under the curve of 0.6269 (95% CI 0.5638-0.6901) for age and BMI, and adding the explained-variance GRS into the model increased the area to 0.6672 (95% CI 0.6064-0.7281) for the prediction of pre-diabetes.
Conclusions:
An explained-variance GRS is associated with both GDM and progression to pre-diabetes and T2D in women with prior GDM.
