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[The efficacy of piribedyl in chronic vascular encephalopathy with mild cognitive impairment]

O A Gan'kina1, E E Vasenina, E D Vasenina

  • 1Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 22, 2014
PubMed

Insights

Piribedyl effectively treats cognitive impairment in chronic vascular encephalopathy (CVE), improving patients' quality of life. Its efficacy is similar whether used alone or with ginkgo biloba.

Area of Science:

  • Neurology
  • Pharmacology

Context:

  • Chronic vascular encephalopathy (CVE) significantly impacts cognitive function and quality of life.
  • Effective symptomatic treatments for cognitive impairment in CVE are needed.

Purpose:

  • To evaluate the efficacy of piribedyl in patients with severe CVE and mild cognitive impairment.

Summary:

  • Thirty-six patients with CVE were treated with piribedyl (50 mg/day for 3 months) as monotherapy or in combination with ginkgo biloba (240 mg/day).
  • Piribedyl demonstrated significant improvement in cognitive impairment and quality of life.
  • Comorbid affective disorders were identified as a predictor for piribedyl's cognitive effects.

Impact:

  • Piribedyl offers a therapeutic option for managing cognitive decline in CVE.
  • The findings suggest that piribedyl is effective in both monotherapy and combination therapy with ginkgo biloba for CVE patients.
Abstract

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