Related Experiment Video
Updated: Apr 26, 2026
10:28
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
16.7K
[REM sleep behavior disorders in Parkinson's disease]
E A Liashenko1, M G Poluéktov, O S Levin
1Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii postdiplomnogo obrazovaniia, Tsentr ékstrapiramidnykh zabolevaniĭ, Moskva.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|July 22, 2014
Summary
REM sleep behavior disorder (RBD) involves acting out dreams due to lost muscle paralysis. This condition is a significant predictor of developing neurodegenerative diseases like Parkinson's.
Area of Science:
- Neurology
- Sleep Medicine
- Neurodegenerative Diseases
Context:
- REM sleep behavior disorder (RBD) is characterized by the loss of muscle atonia during REM sleep.
- This leads to patients physically acting out their dreams, posing risks of injury.
- Idiopathic RBD is increasingly recognized as a prodromal stage of synucleinopathies.
Purpose:
- To review the current literature on REM sleep behavior disorder (RBD).
- To highlight the strong association between idiopathic RBD and subsequent synuclein-mediated neurodegenerative diseases.
- To emphasize the potential of RBD as an early diagnostic marker.
Summary:
- Patients with idiopathic RBD exhibit a high risk (40-65% over 10 years) of developing synucleinopathies.
- These include Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.
- RBD serves as a reliable prodromal marker for these neurodegenerative conditions.
Impact:
- RBD identification offers a window for early intervention and neuroprotective therapies.
- Understanding RBD advances the diagnosis and management of Parkinson's disease and related disorders.
- This research opens avenues for developing treatments to prevent or delay neurodegeneration.
More Related Videos
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.3K
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
1.8K
Related Concept Videos
01:15REM Sleep Behavior Disorder
2.9K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
2.9K
01:24Parkinson Disease l: Introduction
18
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
18
01:15Parkinson's Disease: Overview
2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
01:24Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
01:24Parkinson Disease ll: Pathophysiology
20
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
20
01:24Sleep-Wake Cycles
3.0K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.0K