Related Experiment Video

Updated: Apr 26, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

18.9K

Hippo-YAP signaling pathway: A new paradigm for cancer therapy

Yanlei Ma1, Yongzhi Yang1, Feng Wang1

  • 1Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai, People's Republic of China.

International Journal of Cancer
|July 22, 2014
PubMed

Insights

The Hippo signaling pathway regulates organ size and is implicated in cancer. Its dysregulation is observed in various cancers, making it a target for new cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • The Hippo signaling pathway controls organ size in mammals and Drosophila.
  • It involves a kinase cascade from Mst1/2 to YAP and TAZ.
  • YAP/TAZ are oncogenes, while other Hippo pathway members are tumor suppressors.

Purpose of the Study:

  • To review recent advances in understanding Hippo signaling's role in tumorigenesis.
  • To identify potential therapeutic targets for cancer treatment.

Main Methods:

  • Literature review of studies on Hippo signaling and cancer.
  • Analysis of the Hippo pathway's function in tumorigenesis.

Main Results:

  • Hippo pathway dysregulation is linked to various cancers.
  • YAP/TAZ act as oncogenes, promoting tumor growth.
  • Other Hippo pathway components exhibit tumor-suppressive functions.

Conclusions:

  • The Hippo signaling pathway is a critical regulator in cancer development.
  • Targeting the Hippo pathway offers promising avenues for novel cancer therapies.
Keywords:
cancerhippotherapyyap

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