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PET-positive extralimbic presentation of anti-glutamic acid decarboxylase antibody-associated encephalitis

Gotaro Kojima1, Michiko Inaba2, Michiko K Bruno3

  • 1The John A. Hartford Foundation Center of Excellence in Geriatrics, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, Japan Green Medical Centre, London, UK.

Epileptic Disorders : International Epilepsy Journal with Videotape
|July 22, 2014
PubMed

Insights

Anti-glutamic acid decarboxylase (GAD) antibody-associated autoimmune encephalitis, often limbic, can present with extralimbic involvement. This case highlights extensive brain lesions and the importance of anti-GAD antibody testing in suspected autoimmune encephalitis.

Area of Science:

  • Neurology
  • Immunology
  • Neuroscience

Background:

  • Anti-glutamic acid decarboxylase (GAD) antibody-associated autoimmune encephalitis is typically confined to the limbic system.
  • Extralimbic involvement in anti-GAD antibody encephalitis is rare and poorly understood.
  • This condition is an emerging recognized disease of the central nervous system (CNS).
Keywords:
anti-GAD antibodyautoimmune encephalitisgeneralized seizureglutamic acid decarboxylaselimbic encephalitispalatal myoclonus

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