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Related Experiment Video

Updated: Apr 26, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Molecular pom poms from self-assembling α,γ-cyclic peptides.

Michele Panciera¹, Manuel Amorín, Juan R Granja

¹Department of Organic Chemistry, University of Santiago de Compostela (USC), Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Campus Vida, 15782 Santiago de Compostela (Spain), Fax: (+34) 881 815704.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|July 22, 2014

Summary

Cyclic peptides with nicotinic acid self-assemble into porous, pom-pom-like spheres. These structures encapsulate molecules and enable pyridine-directed metal deposition, showcasing hierarchical self-assembly.

Keywords:

cyclic peptides encapsulation hierarchical processes molecular pom poms self-assembly

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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

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Published on: June 26, 2020

Area of Science:

Supramolecular Chemistry
Materials Science

Background:

Cyclic peptides offer unique structural motifs for self-assembly.
Nicotinic acid and pyridine moieties can direct molecular interactions and functionalization.

Purpose of the Study:

To investigate the hierarchical self-assembly of a novel cyclic peptide.
To explore the encapsulation and surface functionalization capabilities of the self-assembled structures.

Main Methods:

Synthesis of a dimer-forming cyclic peptide incorporating a nicotinic acid moiety.
Characterization of self-assembly using techniques like microscopy and spectroscopy.
Assessment of encapsulation of small organic molecules.
Evaluation of metal deposition on the assembled structures.

Main Results:

The cyclic peptide self-assembles hierarchically into pom-pom-like spherical structures.
The porous nature of these spheres allows for the encapsulation of small organic molecules.
The pyridine moiety effectively directs metal deposition onto the surface of the assembled structures.

Conclusions:

Hierarchical self-assembly of cyclic peptides can yield functional supramolecular materials.
These pom-pom-like structures demonstrate potential for molecular encapsulation and surface modification.
The study highlights the utility of incorporating specific functional moieties for controlled self-assembly and material properties.