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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

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Interplay between estrogen and retinoid signaling in breast cancer--current and future perspectives

Mariana P C Ribeiro1, Armanda E Santos1, José B A Custódio1

  • 1Center for Neuroscience and Cell Biology, University of Coimbra, 3000-354 Coimbra, Portugal; Laboratory of Biochemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.

Cancer Letters
|July 22, 2014
PubMed

Insights

All-trans-retinoic acid (RA) shows promise for breast cancer, but has side effects. Combining RA with antiestrogens like tamoxifen may offer a synergistic therapeutic strategy for breast cancer treatment.

Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • All-trans-retinoic acid (RA) is a potential breast cancer therapeutic agent.
  • Clinical trials with RA in breast cancer patients yielded disappointing outcomes due to adverse effects.
  • Estrogen signaling pathways are implicated in breast cancer development and progression.

Purpose of the Study:

  • To review the interplay between retinoid and estrogen signaling in breast cancer.
  • To explore the synergistic effects of combining RA with antiestrogenic compounds.
  • To evaluate the potential of these combinations for future breast cancer therapy.

Main Methods:

  • Literature review of studies on retinoid and estrogen signaling.
  • Analysis of preclinical and clinical data on RA and antiestrogen combinations.
  • Examination of molecular mechanisms underlying the interplay between these pathways.

Main Results:

  • Retinoid and estrogen signaling pathways exhibit significant interplay in breast cancer.
  • Combination therapy of RA with antiestrogens, such as tamoxifen, demonstrates synergistic effects.
  • These combinations show potential in decreasing breast cancer cell proliferation.

Conclusions:

  • The combination of all-trans-retinoic acid and antiestrogens represents a promising therapeutic strategy for breast cancer.
  • Further research into the interplay between retinoid and estrogen signaling is warranted.
  • Targeting these combined pathways could lead to more effective breast cancer treatments.
Keywords:
Breast cancerEstrogenProliferationRetinoids

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