Related Experiment Video

Updated: Mar 1, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

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Genomic medicine and targeted therapy for solid tumors

Emily A Stevens1, Cristina P Rodriguez

  • 1Seattle Cancer Care Alliance, University of Washington, Seattle, Washington; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington.

Journal of Surgical Oncology
|July 22, 2014
PubMed

Insights

Cancer treatment has shifted from general chemotherapy to targeted therapies by understanding tumor growth mechanisms. This review highlights advances in targeted cancer therapy for epithelial cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Cancer therapy has significantly evolved over the last two decades.
  • Treatment has transitioned from non-specific cytotoxic chemotherapy to targeted therapies.
  • This shift targets specific molecular pathways driving cancer growth.

Purpose of the Study:

  • To review major clinical advances in targeted cancer therapy.
  • Focus on select epithelial malignancies.
  • Emphasize the role of genomic understanding in driving these advances.

Main Methods:

  • Review of clinical advances in targeted cancer therapy.
  • Focus on molecular mechanisms and genomic insights.
  • Analysis of treatment approaches in metastatic and adjuvant settings.

Main Results:

  • Significant progress in targeted therapies for epithelial cancers.
  • Genomic understanding has enabled personalized treatment strategies.
  • Improved outcomes in metastatic and adjuvant cancer treatment.

Conclusions:

  • Targeted cancer therapy, driven by genomic insights, represents a paradigm shift.
  • Understanding molecular mechanisms is crucial for developing effective cancer treatments.
  • Continued research in genomics will further advance epithelial malignancy therapies.
Keywords:
human geneticsindividualized medicinemolecular targeted therapymutationneoplasm

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