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Related Experiment Video

Updated: Apr 26, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Published on: August 11, 2012

Trachoma.

Hugh R Taylor¹, Matthew J Burton², Danny Haddad³

¹Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC, Australia.

Lancet (London, England)

|July 22, 2014

Summary

Trachoma, a leading infectious cause of blindness, is caused by Chlamydia trachomatis. The SAFE Strategy combats this disease through surgery, antibiotics, facial cleanliness, and environmental improvements.

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Last Updated: Apr 26, 2026

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Area of Science:

Ophthalmology
Infectious Diseases
Public Health

Background:

Trachoma is the leading infectious cause of preventable blindness globally.
Childhood Chlamydia trachomatis infections cause conjunctival inflammation and scarring, leading to trichiasis (inturned eyelashes).
Inadequate hygiene in resource-poor settings facilitates disease transmission.

Purpose of the Study:

To summarize the epidemiology, pathophysiology, and control of trachoma.
To highlight the effectiveness of the SAFE Strategy in trachoma elimination efforts.

Main Methods:

Review of epidemiological and pathophysiological data on trachoma.
Description of the integrated SAFE Strategy components: Surgery, Antibiotics, Facial cleanliness, Environmental improvement.

Main Results:

The SAFE Strategy has proven successful in eliminating trachoma in multiple countries.
Global initiatives are actively working towards the worldwide elimination of blinding trachoma.

Conclusions:

Integrated control programs utilizing the SAFE Strategy are effective in combating trachoma.
Continued global efforts are essential to achieve the goal of eliminating blinding trachoma by 2020.