Related Experiment Video

Updated: Apr 26, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

26.6K

Pathological manifestation of difference in washout pattern of adrenal hyperplasia on dynamic CT

Akihiro Nishie1, Yoshiki Asayama, Kousei Ishigami

  • 1Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Journal of Medical Imaging and Radiation Oncology
|July 22, 2014
PubMed

Insights

The clear cell ratio and pre-contrast attenuation on dynamic CT are key factors influencing the washout pattern in adrenal hyperplasia. These findings help explain variations in washout patterns based on cellular composition.

Area of Science:

  • Radiology
  • Pathology
  • Endocrinology

Background:

  • The relationship between adrenal hyperplasia (AH) washout patterns and constituent cells is not well understood.
  • Dynamic CT is a crucial imaging modality for evaluating adrenal lesions.

Purpose of the Study:

  • To identify radiological and pathological factors determining the washout pattern of adrenal hyperplasia (AH) on dynamic CT.
  • To investigate the correlation between cellular composition and washout characteristics in AH.

Main Methods:

  • Dynamic CT scans (pre-contrast, early, and delayed phases) were performed on 10 patients with 14 surgically proven AHs.
  • Absolute Percentage Washout (APW) was calculated using tumor attenuation values.
  • Clear Cell Ratio (CCR) was assessed pathologically, and regression analysis was used to evaluate correlations.

Main Results:

  • A significant correlation was found between Clear Cell Ratio (CCR), pre-contrast attenuation (TApre), and Absolute Percentage Washout (APW).
  • Increased TApre correlated with decreased CCR (r=0.81, P<0.001).
  • Increased APW correlated with decreased CCR (r=0.80, P<0.001) and increased TApre (r=0.74, P<0.01).

Conclusions:

  • Clear Cell Ratio (CCR) and pre-contrast attenuation (TApre) are the primary determinants of the washout pattern in adrenal hyperplasia on dynamic CT.
  • Variability in the APW of AH is associated with differences in its constituent cell types.
Abstract

Keywords:
adrenal hyperplasiaclear cellcompact celllipidwashout

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.1K
Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging09:32

Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging

Published on: December 9, 2021

2.6K

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
27
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
21
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.7K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
5.6K
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
887